Nano SbCl5.SiO2: An efficient and heterogeneous catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-one (thione)derivatives under solvent-free conditions


1 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R.Iran

2 Department of Chemistry, Faculty of Science, Yazd University, Yazd, I.R.Iran


A green approach for efficient and rapid synthesis of biologically active substituted 3,4-dihydropyrimidin-2(1H)-one(thione) derivatives using nano SbCl5.SiO2as a heterogeneous catalyst under solvent-free conditions is reported. The catalyst was characterized by FT-IR, XRD, SEM, TEM and TG-DTG analysis. Compared to the classical reactions, this method consistently has advantages of excellent yields, simple operation, short reaction time, and the avoidance of the use of organic solvents and eco-friendly protocol.