Synthesis of dihydropyrido[2,3-d]pyrimidine derivatives in the presence of sulfonic acid functionalized SBA-15 and the study of their antimicrobial activities

Mohammadi Ziarani, Ghodsi; Hosseini Nasab, Narges; Rahimifard, Mahshid; Badiei, Alireza; Abolhassani Soorki, Ali

Synthesis of dihydropyrido[2,3-d]pyrimidine derivatives in the presence of sulfonic acid functionalized SBA-15 and the study of their antimicrobial activities

Authors

Ghodsi Mohammadi Ziarani ¹

Narges Hosseini Nasab ¹

Mahshid Rahimifard ¹

Alireza Badiei ²

Ali Abolhassani Soorki ³

¹ Department of Chemistry, Alzahra University, Vanak Square, Tehran, Iran

² School of Chemistry, College of Science, University of Tehran, Tehran, Iran

³ ACECR-Research Institute of Applied Sciences, Shahid Beheshti University, Tehran, Iran

Abstract

SBA-Pr-SO3H was used as green and recyclable catalyst for the synthesis of dihydropyrdo[2,3-d]pyrimidine derivatives by three component one-pot reaction between 6-amino-1,3-dimethyl uracil, aromatic aldehydes and 1,3-dicarbonyl compounds under reflux conditions. Some of synthesized dihydropyrido[2,3-d]pyrimidines were showed antimicrobial activities against some fungi and gram positive and negative bacteria

Keywords

6-amino-1

3-dimethyl uracil

pyrido[2

3-d]pyrimidine

3-dicarbonyl compounds

SBA-Pr-SO3H

Multicomponent reaction