Synthesis of dihydropyrido[2,3-d]pyrimidine derivatives in the presence of sulfonic acid functionalized SBA-15 and the study of their antimicrobial activities


1 Department of Chemistry, Alzahra University, Vanak Square, Tehran, Iran

2 School of Chemistry, College of Science, University of Tehran, Tehran, Iran

3 ACECR-Research Institute of Applied Sciences, Shahid Beheshti University, Tehran, Iran


SBA-Pr-SO3H was used as green and recyclable catalyst for the synthesis of dihydropyrdo[2,3-d]pyrimidine derivatives by three component one-pot reaction between 6-amino-1,3-dimethyl uracil, aromatic aldehydes and 1,3-dicarbonyl compounds under reflux conditions. Some of synthesized dihydropyrido[2,3-d]pyrimidines were showed antimicrobial activities against some fungi and gram positive and negative bacteria