Efficient synthesis of highly substituted pyrroles via a multi-component reaction using ZnO nanoparticles as a nanocatalyst


1 Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, Tehran, Iran

2 Department of Chemistry, Science and Research Branch, Islamic Azad University, Tehran, Iran


Aconvenient one-pot multi-component reaction of aromatic aldehydes, 1,3-dicarbonyl compounds, amine and nitromethane in the presence of 10 mol % ZnO nanoparticles for the synthesis of highly substituted pyrroles is described. The products were obtained in moderate to good yields via one-pot tandem reaction. This method offers several advantages such as good yields, simple procedure, non hazardous reaction condition and starting from easily accessible substrates.