A Simple Approach to the Synthesis of 3-Substituted Rhodanines and Thiazolidine-2,4-diones

Authors

1 Department of Chemistry and Petrochemical Engineering, Standard Research Institute (SRI), Karaj, Iran

2 Department of Chemistry, Sharif University of Technology, Tehran, Iran

Abstract

A novel synthesis of 3-substituted rhodanine and thiazolidine-2,4-dione derivatives starting from aliphatic primary amines, carbon disulfide, and methyl 2-bromoacetate is described. The reaction proceeds successfully both in water and under solvent-free conditions, but 2-thioxothiazolidin-4-one (rhodanine) derivatives were obtained under solvent free-conditions, and thiazolidine-2,4-dions were formed when water was used as the solvent.

Keywords


Volume 20, Issue 6 - Serial Number 13
Transactions on Chemistry and Chemical Engineering (C)
December 2013
Pages 1833-1838
  • Receive Date: 03 August 2013
  • Revise Date:
  • Accept Date: 27 July 2017