Synthesis of Hybrid Se-SiNPs Nanoparticle for the Studies of Cellular Toxicity against Breast Cancer Cell Line MCF-7

Kumar, Anil; Bera, Smritilekha; Singh, Man; Mondal, Dhananjoy

doi:10.24200/sci.2023.57071.5050

Synthesis of Hybrid Se-SiNPs Nanoparticle for the Studies of Cellular Toxicity against Breast Cancer Cell Line MCF-7

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Document Type : Article

Authors

¹ School of Nano Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India-382030

² School of Chemical Sciences, Central University of Gujarat, Gandhinagar, Gujarat, India-382030

10.24200/sci.2023.57071.5050

Abstract

A hybrid nanocomposite of biologically compatible silica nanoparticles (SiNPs) coated with selenium nanoparticles (SeNPs) was developed and evaluated for cytotoxicity on the breast cancer cell line using MTT assay methods. The hybrid nanoparticles were characterized by DLS, XRD and SEM spectroscopy. The size and size distribution of SiNPs and composite Se-SiNPs nanoparticles determined by DLS experiment are SiNPs and Se-SiNPs 23.85 and 89.9 nm in diameter respectively. The Se-SiNPs hybrid nanomaterials showed higher cytotoxicity than pure SiNPs against the breast cancer cell line MCF-7. When compared to SiNPs, composite Se-SiNPs suppressed the growth of the breast cancer cell line MCF-7.

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