A Flexible one-pot synthesis of pyrazolopyridines catalyzed by Fe3O4@SiO2-SO3H nanocatalyst under microwave irradiation


Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, Iran.


Fe3O4@SiO2-SO3H nanocatalyst has been used as an ecient catalyst for the preparation of pyrazolopyridines by a multi-component reaction of ethyl acetoacetate, aldehyde, hydrazine hydrate, and ammonium acetate under microwave irradiation. Atom economy, wide range of products, excellent yields in short times, use of microwave as green method, reusability of the catalyst, and little catalyst loading are some of the important features of this protocol.


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