Synthesis of 1, 4-dihydropyridines (DHP) Catalyzed by Trichloroisocyanuric Acid (TCCA) in Aqueous Media

Authors

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Abstract

An array of 1, 4-dihydropyridines (DHP) derivativeswas synthesized by Hantzsch three-component reaction of aromatic aldehydes, ethyl acetoacetate and ammonium acetate using trichloroisocyanuric acid (TCCA) as an efficient catalyst in aqueous media. The proposed method was operationally simple and to make the process benign for the environment, water used as a reaction medium. No aromatization of dihydropyridinesproducts was done in the presence of TCCA as an oxidant.

Keywords


Volume 23, Issue 6 - Serial Number 6
Transactions on Chemistry and Chemical Engineering (C)
December 2016
Pages 2756-2761
  • Receive Date: 15 November 2015
  • Revise Date: 21 December 2024
  • Accept Date: 27 July 2017