An Efficient One-pot Three-component Synthesis of Pyrido[2,3-d]pyrimidine Derivatives in the Presence of Nano Silica-supported Preyssler H14[NaP5W30O110]/SiO2 as a Green and Reusable Catalyst


1 Department of Chemistry, School of Sciences, Alzahra University, P.O. Box 1993891176, Vanak, Tehran, Iran

2 Department of Chemistry, Islamic Azad University-Mashhad Branch, Mashhad, Iran


An efficient and mild condensation reaction of 6-aminouracil derivatives with various aromatic aldehydes and ethyl or methyl acetoacetate was performed in the presence of catalytic amounts of H14[NaP5W30O110]/SiO2 as a recyclable, eco-friendly and green nano-catalyst to afford the desired pyrido[2,3-d]pyrimidine derivatives in good to excellent yields.