Evaluation of the e ffects of nano-TiO2 on physical and mechanical properties of nano-bioglass 45S5 sca old for bone tissue engineering


1 Department of Science and Nuclear Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran.

2 Biomaterials Group, Advance Medical Technology Department, Isfahan University of Medical Sciences, Isfahan, Iran

3 Department of Material Engineering, Isfahan University of Technology, Isfahan, Iran


Design of a sca old with appropriate physical and mechanical properties for tissue engineering is a major challenge. In this research, the e ects of nano-titania (nTiO2) on the physical and mechanical properties of a nano-bioglass (nBG) sca old were evaluated. First, nBG powder with a grain size of 100-110 nm was prepared using the method of melting pure raw material at a temperature of 1400C. Then, a porous ceramic sca old of nBG/nTiO2, with 30 wt% of nBG, containing di erent weight ratios of nano-titania (3, 6 and 9 wt% nTiO2 with a grain size of 35-37 nm), was prepared using the polyurethane sponge replication method. XRD, XRF, SEM, FE-SEM and FTIR were used to study the phase and elemental structures, morphology, particle size, and determination of functional  groups, respectively. XRD and XRF results showed that the type of produced bioglass was 45S5. he results of XRD and FT-IR showed that the best temperature to produce a bioglass sca old was 600C, because, at this temperature, the crystal was obtained, and the main sign of the obtained crystal was the presence of Na2Ca2Si3O9 crystal. The mechanical strength and modulus of the sca old improved by adding nTiO2 to the nBG sca old. The results showed that the sca olds have 80-88% porosity at the range of 200- 600 m; a compressive strength of 0.04-0.16 MPa, and a compressive modulus of 4-13.33 MPa, illustrating that they could be good candidates for bone tissue engineering.