Citric acid as an ecient and trifunctional organo catalyst for one-pot synthesis of new indolenines by Fischer's method at reflux condition in ethanol

Authors

1 Faculty of Chemistry, Bu-Ali Sina University, Hamedan, P.O. Box 6517838683, Iran

2 Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran.

3 Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Zip Code 65178, Hamadan, Iran

Abstract

New indolenines I(1-18) were prepared by Fischer indole synthetic reaction of hydrazines derivatives H(1-6) with isoproylmethylketone K1, 2-methylcyclohexanone K2 and diisopropyl ketone K3 in presence of citric acid as a new catalyst at reflux condition in high yield.

Keywords

Scientia Iranica
Volume 21, Issue 6 - Serial Number 6
Transactions on Chemistry and Chemical Engineering (C)
December 2014
Pages 2059-2065

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History

  • Receive Date: 29 December 2014
  • Revise Date: 21 December 2024
  • Accept Date: 27 July 2017

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