Citric acid as an ecient and trifunctional organo catalyst for one-pot synthesis of new indolenines by Fischer's method at reflux condition in ethanol


1 Faculty of Chemistry, Bu-Ali Sina University, Hamedan, P.O. Box 6517838683, Iran

2 Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran.

3 Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Zip Code 65178, Hamadan, Iran


New indolenines I(1-18) were prepared by Fischer indole synthetic reaction of hydrazines derivatives H(1-6) with isoproylmethylketone K1, 2-methylcyclohexanone K2 and diisopropyl ketone K3 in presence of citric acid as a new catalyst at reflux condition in high yield.