Scientia Iranica

Scientia Iranica

Citric acid as an ecient and trifunctional organo catalyst for one-pot synthesis of new indolenines by Fischer's method at reflux condition in ethanol

Authors
M.A. Zolfigol 1
S. Sajjadifar 2
Gh. Chehardoli 3
N. Javaherneshan 1
1 Faculty of Chemistry, Bu-Ali Sina University, Hamedan, P.O. Box 6517838683, Iran
2 Department of Chemistry, Payame Noor University, Tehran, P.O. Box 19395-4697, Iran.
3 Department of Medicinal Chemistry, School of Pharmacy, Hamadan University of Medical Sciences, Zip Code 65178, Hamadan, Iran
Abstract
New indolenines I(1-18) were prepared by Fischer indole synthetic reaction of hydrazines derivatives H(1-6) with isoproylmethylketone K1, 2-methylcyclohexanone K2 and diisopropyl ketone K3 in presence of citric acid as a new catalyst at reflux condition in high yield.
Keywords
3H-indole
Indolenine
Fischer's reaction
Citric acid
Green synthesis
Scientia Iranica
Volume 21, Issue 6 - Serial Number 6
Transactions on Chemistry and Chemical Engineering (C)
December 2014
Pages 2059-2065

  • Receive Date 29 December 2014
  • Accept Date 27 July 2017