1
Department of Chemistry, Najafabad Branch, Islamic Azad University, Isfahan, Iran
2
Laboratory of Organic Chemistry Research, Department of Organic Chemistry, College of Chemistry, University of Kashan, 87317-51167, Kashan, Iran
Abstract
A mild, efficient and environmentally friendly method has been developed for the green synthesis of 2,4,5-trisubstituted imidazoles via a three-component one-pot condensation of 1,2-diketones, diammonium hydrogen phosphate, (NH4)2HPO4(DAHP) and aryl aldehydes in waterunder reflux conditions. The DAHP shows remarkable activities for the synthesis of title compounds.The key advantages of this method toward conventional methods are experimental simplicity, good functional group tolerance; excellent yields, short routine, and selectivity without the need for a transition metal or base catalyst.
Dehghan Khalili,S , Banitaba,S H and Safari,J . (2013). An efficient method for the catalyst-free one-pot green synthesis of 2,4,5-trisubstituted imidazoles in water. Scientia Iranica, 20(6), 1855-1862.
MLA
Dehghan Khalili,S , , Banitaba,S H , and Safari,J . "An efficient method for the catalyst-free one-pot green synthesis of 2,4,5-trisubstituted imidazoles in water", Scientia Iranica, 20, 6, 2013, 1855-1862.
HARVARD
Dehghan Khalili S, Banitaba S H, Safari J. (2013). 'An efficient method for the catalyst-free one-pot green synthesis of 2,4,5-trisubstituted imidazoles in water', Scientia Iranica, 20(6), pp. 1855-1862.
CHICAGO
S Dehghan Khalili, S H Banitaba and J Safari, "An efficient method for the catalyst-free one-pot green synthesis of 2,4,5-trisubstituted imidazoles in water," Scientia Iranica, 20 6 (2013): 1855-1862,
VANCOUVER
Dehghan Khalili S, Banitaba S H, Safari J. An efficient method for the catalyst-free one-pot green synthesis of 2,4,5-trisubstituted imidazoles in water. Scientia Iranica. 2013;20(6):1855-1862.
