1
Department of Chemistry,Sharif University of Technology
2
Department of Chemistry,University of Leeds
3
Department of Chemistry,University of Kerman
Abstract
A sensitive colorimetric method for the detection of ascorbic acid was proposed in this
research based on the reduction of silver ions by ascorbic acid in the presence of citrate-stabilized silver
seeds, additional trisodium citrate and a polymer such as polyvinylpyrrolidone. The color of the stable sol
is controlled by varying the concentration of trisodium citrate (TSC), polyvinylpyrrolidone, silver nitrate
and silver seeds. The reduction of Ag+ to triangle silver nanoparticles (Ag-NPs) by ascorbic acid in the
presence of trisodium citrate (TSC) and silver seeds produced two very intense surface plasmon resonance
peaks of Ag-NPs. The plasmon absorbance of Ag-NPs allows the quantitative spectrophotometric detection
of the ascorbic acid. The calibration curve derived from the changes in absorbance at = 427 nm was
linear, with the concentration of ascorbic acid in the range of 6:010????6 to 8:010????5 M. The method was
applied to the determination of ascorbic acid in pharmaceutical formulations with satisfactory results.
Hormozi Nezhad,M R , Karimi,M and Shahheydari,F . (2010). A Sensitive Colorimetric Detection of Ascorbic Acid in Pharmaceutical Products Based on Formation of Anisotropic Silver Nanoparticles. (e3385). Scientia Iranica, 17(2), e3385
MLA
Hormozi Nezhad,M R , , Karimi,M , and Shahheydari,F . "A Sensitive Colorimetric Detection of Ascorbic Acid in Pharmaceutical Products Based on Formation of Anisotropic Silver Nanoparticles" .e3385 , Scientia Iranica, 17, 2, 2010, e3385.
HARVARD
Hormozi Nezhad M R, Karimi M, Shahheydari F. (2010). 'A Sensitive Colorimetric Detection of Ascorbic Acid in Pharmaceutical Products Based on Formation of Anisotropic Silver Nanoparticles', Scientia Iranica, 17(2), e3385.
CHICAGO
M R Hormozi Nezhad, M Karimi and F Shahheydari, "A Sensitive Colorimetric Detection of Ascorbic Acid in Pharmaceutical Products Based on Formation of Anisotropic Silver Nanoparticles," Scientia Iranica, 17 2 (2010): e3385,
VANCOUVER
Hormozi Nezhad M R, Karimi M, Shahheydari F. A Sensitive Colorimetric Detection of Ascorbic Acid in Pharmaceutical Products Based on Formation of Anisotropic Silver Nanoparticles. Scientia Iranica. 2010;17(2):e3385.
