Spectroscopic and Thermodynamic Studies of Interaction Between Dopamine and Cobalt(III) Schi -Base Complexe


Department of Chemistry,Sharif University of Technology


In this paper, the interactions of cobalt(III) tetradentate Schi -base complexes, [Co(3-
MeO-salophen)]ClO4, (1), [Co(5-NO2-salophen)]ClO4, (2), and [Co(5-Br-salophen)]ClO4, (3), with
dopamine, an important neurotransmitter, have been investigated. The formation and kinetic constants for
complex formation of [Co(3-MeO-salophen)]ClO4, (1), with dopamine were determined spectrophotometrically
in H2O/EtOH solution (4:1) at 30 C by using the Benesi-Hildbrand and Guggenheim equations,
respectively. The stoichiometry has been found to be 1:1. The rate and equilibrium constants for the
coordination of dopamine to [Co(3-MeO-salophen)]ClO4 were found to be 0.0053 min????1 and 1600 dm3
mol????1, respectively.