A Novel Synthesis of 2-(Alkylamino) and 2-(Arylamino)- 4(3H) Quinazolinones by Heterotrocyclization of 2-Aminobenzamide with Isothiocyanates (or Isocyanates) under Microwave Irradiation


Department of Chemistry,Ferdowsi University of Mashhad


A convenient one-pot preparation of 2-(alkylamino) and 2(arylamino)-4(3H) quinazolinones in high yields has been developed by microwave induced heterocyclization of 2-aminobenzamide with isothiocyanates (or Isocyanates) in solvent-free conditions. In comparison, the reactions are faster under microwave irradiation and the yields are much higher than those by/of conventional heating (under reflux in toluene).