A multi-component reaction for the direct access to 4,4'-(phenylmethylene)bis(1H-pyrazol-5-ol)-3-carboxylates using nano-NiZr4(PO4)6 in water

Document Type : Article

Authors

1 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, P.O. Box 87317-51167, I. R. Iran

2 School of Chemistry, College of Science, University of Tehran, Tehran 14155-6455, Iran

Abstract

An efficient synthesis of 4,4'-(phenylmethylene)bis(1H-pyrazol-5-ol)-3-carboxylates is achieved by one pot pseudo five-component reaction of phenylhydrazine, acetylenedicarboxylates and aromatic aldehydes in the presence ofnano-NiZr4(PO4)6 at 60°C in water. Nano-NiZr4(PO4)6  has been characterized by powder X-ray diffraction (XRD) and scanning electronic microscopy (SEM). Use of simple and readily available starting materials, excellent yields in short times, reusability of the catalyst, little catalyst loading and simple operational procedures are some of the important features of this protocol.

Keywords

Main Subjects


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Volume 25, Issue 6
Transactions on Chemistry and Chemical Engineering (C)
November and December 2018
Pages 3288-3294
  • Receive Date: 23 December 2016
  • Revise Date: 11 October 2017
  • Accept Date: 14 May 2018