1
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran
2
Department of Organic Chemistry, Faculty of Chemistry, Yazd University, Yazd, I.R. Iran
10.24200/sci.2020.54203.3646
Abstract
Fused benzo-4H-pyran, namely, 4H-chromene moiety is the leading formation block of several heter-ocyclic natural products with biological activity such as, antioxidant, antibacterial, antiviral, antifun-gal, hypotensive, diuretic, and antiallergenic, antileishmanial, anticoagulant and antitumor. Herein, one-pot three components of aldehyde, malononitrile and enolizable compounds in the presence of nano-kaoline/BFn/Fe3O4 catalytic system to improve the 4H-chromenes via domino Knoevenagel-Michael-cyclization coupling reaction is reported. The advantages of this protocol involve high yield of products, use of solvent-free condition, easy experimental work-up system, low reaction times, re-cyclable catalyst and green process which privilege it as an alternative for other analogous synthetic procedures. The structure of synthesized 4H-chromenes were elucidated by FT-IR, 1H NMR and 13C NMR.
Mohammadipour, R., Bamoniri, A., Mirjalili, B. (2020). Green one-pot three-component synthesis of 4H-chromenes in the presence of nano-kaoline/BF3/Fe3O4 as a super paramagnetic nanocatalyst. Scientia Iranica, 27(3), 1216-1225. doi: 10.24200/sci.2020.54203.3646
MLA
Reza Mohammadipour; A. Bamoniri; Bi Bi Fatemeh Mirjalili. "Green one-pot three-component synthesis of 4H-chromenes in the presence of nano-kaoline/BF3/Fe3O4 as a super paramagnetic nanocatalyst". Scientia Iranica, 27, 3, 2020, 1216-1225. doi: 10.24200/sci.2020.54203.3646
HARVARD
Mohammadipour, R., Bamoniri, A., Mirjalili, B. (2020). 'Green one-pot three-component synthesis of 4H-chromenes in the presence of nano-kaoline/BF3/Fe3O4 as a super paramagnetic nanocatalyst', Scientia Iranica, 27(3), pp. 1216-1225. doi: 10.24200/sci.2020.54203.3646
VANCOUVER
Mohammadipour, R., Bamoniri, A., Mirjalili, B. Green one-pot three-component synthesis of 4H-chromenes in the presence of nano-kaoline/BF3/Fe3O4 as a super paramagnetic nanocatalyst. Scientia Iranica, 2020; 27(3): 1216-1225. doi: 10.24200/sci.2020.54203.3646
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