TY - JOUR ID - 21790 TI - Green one-pot three-component synthesis of 4H-chromenes in the presence of nano-kaoline/BF3/Fe3O4 as a super paramagnetic nanocatalyst JO - Scientia Iranica JA - SCI LA - en SN - 1026-3098 AU - Mohammadipour, R. AU - Bamoniri, A. AU - Mirjalili, B.F. AD - Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R. Iran AD - Department of Organic Chemistry, Faculty of Chemistry, Yazd University, Yazd, I.R. Iran Y1 - 2020 PY - 2020 VL - 27 IS - 3 SP - 1216 EP - 1225 KW - One-pot three components KW - Nano-kaoline/BFn/Fe3O4 KW - 4H-chromenes KW - Solvent-free condition DO - 10.24200/sci.2020.54203.3646 N2 - Fused benzo-4H-pyran, namely, 4H-chromene moiety is the leading formation block of several heter-ocyclic natural products with biological activity such as, antioxidant, antibacterial, antiviral, antifun-gal, hypotensive, diuretic, and antiallergenic, antileishmanial, anticoagulant and antitumor. Herein, one-pot three components of aldehyde, malononitrile and enolizable compounds in the presence of nano-kaoline/BFn/Fe3O4 catalytic system to improve the 4H-chromenes via domino Knoevenagel-Michael-cyclization coupling reaction is reported. The advantages of this protocol involve high yield of products, use of solvent-free condition, easy experimental work-up system, low reaction times, re-cyclable catalyst and green process which privilege it as an alternative for other analogous synthetic procedures. The structure of synthesized 4H-chromenes were elucidated by FT-IR, 1H NMR and 13C NMR. UR - https://scientiairanica.sharif.edu/article_21790.html L1 - https://scientiairanica.sharif.edu/article_21790_4293ac3a255d7b809057a61fc2fc5776.pdf ER -