Impact of electrospun Tecophilic/gelatin scaffold biofunctionalization on proliferation of vascular smooth muscle cells

Document Type: Article

Authors

1 Department of Cellulose and Paper Technology, Faculty of New Technologies and Energy Engineering, Shahid Beheshti University, Zirab Campus, Mazandaran, 4781173769, Iran

2 Department of Mechanical Engineering, Faculty of Engineering, 2 Engineering Drive 3, National University of Singapore, Singapore 117576, Singapore

Abstract

Nanofibrous composite scaffolds based on Tecophilic (TP) and gelatin (gel) were electrospun and further modification of their surfaces was performed by adsorption of gelatin or fibronectin biomolecules. The ability of coated scaffolds to alter the proliferation rate of smooth muscle cells (SMCs) was investigated via various assays and compared to cell proliferation on non-coated scaffolds. The results confirmed the potential of both coated and non-coated composite scaffolds to support SMC growth. Although, the presence of fibronectin increased the proliferation, adsorbed gelatin could reduce the proliferation of SMCs. The success of a tissue engineered vascular graft depends on the ability of the scaffold to control the proliferation rate of SMCs and thus our study provides a better insight towards the fabrication of functional constructs for vascular regeneration.

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