Department of Science and Nuclear Engineering, Najafabad Branch, Islamic Azad University, Najafabad, Isfahan, Iran.
Biomaterials Group, Advance Medical Technology Department, Isfahan University of Medical Sciences, Isfahan, Iran
Department of Material Engineering, Isfahan University of Technology, Isfahan, Iran
Design of a scaold with appropriate physical and mechanical properties for tissue engineering is a major challenge. In this research, the eects of nano-titania (nTiO2) on the physical and mechanical properties of a nano-bioglass (nBG) scaold were evaluated. First, nBG powder with a grain size of 100-110 nm was prepared using the method of melting pure raw material at a temperature of 1400C. Then, a porous ceramic scaold of nBG/nTiO2, with 30 wt% of nBG, containing dierent weight ratios of nano-titania (3, 6 and 9 wt% nTiO2 with a grain size of 35-37 nm), was prepared using the polyurethane sponge replication method. XRD, XRF, SEM, FE-SEM and FTIR were used to study the phase and elemental structures, morphology, particle size, and determination of functional groups, respectively. XRD and XRF results showed that the type of produced bioglass was 45S5. he results of XRD and FT-IR showed that the best temperature to produce a bioglass scaold was 600C, because, at this temperature, the crystal was obtained, and the main sign of the obtained crystal was the presence of Na2Ca2Si3O9 crystal. The mechanical strength and modulus of the scaold improved by adding nTiO2 to the nBG scaold. The results showed that the scaolds have 80-88% porosity at the range of 200- 600 m; a compressive strength of 0.04-0.16 MPa, and a compressive modulus of 4-13.33 MPa, illustrating that they could be good candidates for bone tissue engineering.