An efficient synthesis of pyrimido[4,5-b]quinoline and indenopyrido[2,3-d]pyrimidine derivatives in the presence of Fe3O4@nano-cellulose/Sb(V) as bio-based magnetic nano-catalyst

Document Type : Article

Authors

1 Department of Chemistry, College of Science, Yazd University, Yazd, P.O.Box: 89195-741, Iran

2 Department of Chemistry, College of Science, Yazd University, Yazd, P.O.Box 89195-741, Iran

3 Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan, I.R.IRAN

10.24200/sci.2021.56414.4712

Abstract

In this study, an eco-friendly approach has been introduced for the synthesis of pyrimido[4,5-b]quinolones and indenopyrido[2,3-d]pyrimidines. This synthesis was done via a three component coupling of 6-amino-2-(methylthio)pyrimidin-4(3H)-one, 1,3-indanedione/dimedone and aromatic aldehydes using Fe3O4@nano-cellulose/Sb(V) as catalyst under solvent-free condition at 70 °C by electrical mortar-heater. The catalyst was separated from the reaction mixture by an external magnet and reused for subsequent reactions. The present procedure offers many advantages such as high yield, easy work-up, simple isolation of catalyst by external magnet and high reusability of the it. The structure of the obtained pyrimido[4,5-b]quinolones and indenopyrido[2,3-d]pyrimidines products were studied by FT-IR, 1H-NMR and 13C-NMR spectroscopic data.

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