A new and efficient method for the synthesis of pyrazolo[3,4-d] pyrimidines catalyzed by iodine

Document Type : Article


Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, PO Box 111559516, Tehran, Iran


Fully substituents new pyrazolo[3,4-d]pyrimidines were synthesized. The synthesis starts with cyanomethylphenylketone that reacts with phenyl hydrazine to give the corresponding aminopyrazole. The latter undergoes a cyclocondensation with an N,N'-bis(arylmethylidene)arylmethane yielding the final product. Both synthetic steps are high-yielding (the overall yields between 65-78%). The newly synthesized compounds were characterized by 1H NMR, 13C NMR and elemental analysis


Main Subjects

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