MCM-41-SO3H as an efficient reusable nano-ordered heterogeneous catalyst for the synthesis of divers 1- & 5-substituted 1H-tetrazoles

Document Type: Article

Authors

Laboratory of Organic Synthesis and Natural Products, Department of Chemistry, Sharif University of Technology, PO Box 111559516, Tehran, Iran

Abstract

An improved and efficient method for the synthesis of 1- & 5-substituted 1H-tetrazole derivatives has been described in the presence of nano-ordered MCM-41-SO3H as an effective heterogeneous catalyst. This metal-free protocol, [2+3] cycloaddition of sodium azide to various nitriles or ethyl N-phenyl formimidate intermediate under mild reaction conditions, afford a wide range of 1H-tetrazoles in good to excellent yields. The catalyst was reused for five times without significant loss of catalytic activity.

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