Sharif University of Technology Scientia Iranica 1026-3098 25 3 2018 06 01 Plasmonic Circular Dichroism Study of Gold Nanorod-Quadruplex Nanobioconjugates 1783 1788 4431 10.24200/sci.2017.4431 EN Zeinab Bagheri Protein Research Center, Shahid Beheshti University G.C., Velenjak Tehran, Iran Bijan Ranjbar Department of Biophysics, Faculty of Biological Sciences, Tarbiat Modares University, 154-14115 Tehran, Iran Azadeh Azizi Department of Bioscience and Biotechnology, Malik-Ashtar University of Technology, Tehran, Iran Hamid Latifi 5- Laser and Plasma Research Institute, Shahid Beheshti University G.C., Velenjak Tehran. Iran. Mohammad Ismail Zibaii 5- Laser and Plasma Research Institute, Shahid Beheshti University G.C., Velenjak Tehran. Iran Tahereh Tohidi Moghadam Department of Nanobiotechnology, Faculty of Biological Sciences, Tarbiat Modares University, 154-14115 Tehran, Iran Journal Article 2014 08 01 Circular dichroism spectroscopy is a simple way to study G-quadruplex structure and is very useful for monitoring the conformational changes in G-quadruplex structure induced by modifications of the environment. Plasmonic nanoparticles with localized surface plasmon resonance (LSPR) can create strong electromagnetic fields at the surface of plasmonic metals, which remarkably influence the optical properties of molecules. Plasmonic CD is a new CD signal which originates from the dipole–dipole interactions between surface plasmons of NPs and chiral biomolecules have received interest research in various fields of nanotechnology. In this paper we study the interaction between gold nanorods (GNR) and two types of G-quadruplex (parallel and antiparallel), to monitor the alterations in DNA conformation and plasmonic CD signal upon formation of GNR-quadruplex nanobioconjugate. The results from this study indicate the plasmonic CD signals in visible regions are more sensitive than Far-UV CD signals to detect the spatial conformational state of G-quadruplex-GNR nanobioconjugate.  https://scientiairanica.sharif.edu/article_4431_0702d35f7b6ac2010ba967be6d688e9f.pdf