Sharif University of Technology Scientia Iranica 1026-3098 16 2 2009 12 01 Highly Ecient One-Pot Three-Component Mannich Reaction Under Solvent-Free Conditions 3271 EN N. Azizi Research Center,University of Tehran M.R. Saidi Department of Chemistry,Sharif University of Technology F. Ebrahimi Department of Chemistry,Sharif University of Technology Journal Article 2010 05 12 A mild and practically-convenient one-pot procedure for the direct Mannich reaction has been developed using a condensation of amines, aldehydes and unmodied ketones under solvent free conditions in the presence of ZnI2 with good to excellent yields. The present methodology oers several advantages, such as excellent yields, simple procedures, short reaction times and milder conditions with very small amounts of catalyst. Furthermore, it is the rst time that the catalytic activity of several catalysts under solvent free conditions has been studied. It was found that both the diastereoselectivity and the rate of reaction were improved with various Lewis acids and metal oxides. However, the chiral catalysts, such as L-cystine, (-)-cinchonidine and L-proline, did not work well in terms of yield and diastereoselectivity under this condition. https://scientiairanica.sharif.edu/article_3271_592f60adb7d3ba9f7511cf6eb6609ccd.pdf