Sharif University of Technology Scientia Iranica 1026-3098 29 6 2022 12 01 Nano CaO: Synthesis, characterization, and application as an efficient catalyst for the preparation of tetrazole analogues of protected amino acids 3132 3141 22844 10.24200/sci.2022.58638.5826 EN H. S. Lalithamba Department of Chemistry, Siddaganga Institute of Technology, B.H. Road, Tumakuru-572 103, Karnataka, India 0000-0001-6047-8493 M. Raghavendra Department of Chemistry, Siddaganga Institute of Technology, B.H. Road, Tumakuru-572 103, Karnataka, India R. Bharath Department of Chemistry, Siddaganga Institute of Technology, B.H. Road, Tumakuru-572 103, Karnataka, India H. K. E. Latha Department of Electronics & Instrumentation Engineering, Siddaganga, Institute of Technology, B.H. Road, Tumakuru-572 103, Karnataka, India 0000-0002-6594-8359 N. Bharath Department of Chemistry, Siddaganga Institute of Technology, B.H. Road, Tumakuru-572 103, Karnataka, India Journal Article 2021 07 11 Nano CaO as a recyclable heterogeneous catalyst was synthesized via solution combustion method using Black pepper seed extract as a fuel, calcium nitrate as a source of calcium and characterized by various techniques such as XRD, FT-IR, EDAX, and SEM analysis. The catalyst was established a superior catalytic activity towards the synthesis of tetrazole analogues of protected amino acids in good yield via cycloaddition reaction of sodium azides with protected nitriles in methanol and water system under reflux condition. The synthesized N-protected tetrazoles were characterized by mass, FT-IR, 1H NMR, and 13C NMR. The experiment clarifies the shorter reaction time, inexpensive catalyst which is easily separable by simple filtration, and catalysts can be reused for several times without significant degradation in activity. https://scientiairanica.sharif.edu/article_22844_ae6a757b965961ebbec156a82c5c9f40.pdf