TY - JOUR ID - 4523 TI - Toxic Effects of Chronic Feeding with Food Azo Dyes on Drosophila melanogaster Oregon R JO - Scientia Iranica JA - SCI LA - en SN - 1026-3098 AU - Uysal, Handan AU - Genç, Sıdıka AU - Ayar, Arif AD - Department of Biology, Faculty of Science, Atatürk University, 25240, Erzurum, Turkey AD - Sabuncuoğlu Şerefeddin Health Services Vocational School, Amasya University, 05100, Amasya, Turkey Y1 - 2017 PY - 2017 VL - 24 IS - 6 SP - 3081 EP - 3086 KW - Drosophila melanogaster KW - Food Azo dyes KW - Longevity KW - Larval mortality KW - Toxic effects DO - 10.24200/sci.2017.4523 N2 - Artificial azo dyes are widely used as coloring agents for foodstuffs, drugs and cosmetics. In this study, the toxic effect of four different synthetic food dyes (Ponceau 4R, Sunset Yellow, Amaranth, Tartrazine) on 72±4h larvae of Oregon (R) wild type of Drosophila melanogaster were investigated. In addition, depending on chronic feeding, the life span of the flies determined. For this purpose, six different concentrations of the food dyes (5, 10, 15, 20, 25 and 30 mg mL-1) were selected by preliminary studies to determine the LD100 values.The effects of the food dyes on longevity were studied separately in female and male populations. It was determined that the maximum mean life span of the female and male D. melanogaster populations decreased with increasing concentrations of food dyes. Based on the results obtained from the larval mortality and life span experiments, the order of toxicity for food dyes was Tartrazine>Amaranth> Sunset Yellow ≥ Ponceau 4R. UR - https://scientiairanica.sharif.edu/article_4523.html L1 - https://scientiairanica.sharif.edu/article_4523_ea46e8cc5bc59bf81eb4cbf1c15c6778.pdf ER -