TY - JOUR ID - 21565 TI - Synthesis and structure-activity relationship of 1-[(E)-3-phenyl-2-propenyl] piperazine derivatives as suitable antibacterial agents with mild hemolysis JO - Scientia Iranica JA - SCI LA - en SN - 1026-3098 AU - Abbasi, M.A. AU - Nazir, M. AU - Aziz-ur-Rehman, Aziz-ur-Rehman AU - SIDDIQUI, S.Z. AU - Shah, S.A.A. AU - Shahid, M. AD - Department of Chemistry, Government College University, Lahore-54000, Pakistan. AD - Faculty of Pharmacy and Atta-ur-Rahman Institute for Natural Products Discovery (AuRIns), Level 9, FF3, Universiti Teknologi MARA, Puncak Alam Campus, 42300 Bandar Puncak Alam, Selangor Darul Ehsan, Malaysia AD - Department of Biochemistry, University of Agriculture, Faisalabad-38040, Pakistan Y1 - 2019 PY - 2019 VL - 26 IS - 6 SP - 3375 EP - 3386 KW - 1-[(E)-3-phenyl-2- propenyl]piperazine KW - Bromoacetyl bromide KW - Amides KW - Biofilm inhibition KW - Hemolysis DO - 10.24200/sci.2019.51207.2062 N2 - A new series of 1-[(E)-3-phenyl-2-propenyl]piperazine derivatives (5a-m) as antibacterial agents was designed and synthesized. The synthetic strategy was initiated by coupling different anilines (1a-m) with bromoacetyl bromide (2) in aqueous basic medium to acquire different electrophiles, 3a-m, with good yields. These electrophiles were further reacted with 1-[(E)-3-phenyl-2-propenyl]piperazine (4) to yield the desired compounds, N-(substituted)-2-{4-[(E)-3-phenyl-2-propenyl]-1-perazinyl}acetamides (5a-m). The structures of these compounds were established from their IR, 1H-NMR, 13C-NMR, EI-MS and CHN analysis data. The bacterial biofilm inhibitory potential of these piperazine derivatives was tested against two pathogenic strains, Bacillus subtilus and Escherichia coli. Two compounds, 5d and 5h were identified as suitable antibacterial agents. The cytotoxicity of these molecules was profiled through hemolytic assay and it was inferred that all the compounds were nearly harmless for membrane of red blood cells. UR - https://scientiairanica.sharif.edu/article_21565.html L1 - https://scientiairanica.sharif.edu/article_21565_39b39656641af9ef0d875858813f90ad.pdf ER -