@article { author = {Haddad, Abbas and Taajobian, Maryam and Jahanian, Ali}, title = {Massive Parallel Digital Micro fluidic Biochip Architecture for Automating Large-Scale Biochemistry Assays}, journal = {Scientia Iranica}, volume = {25}, number = {6}, pages = {3461-3474}, year = {2018}, publisher = {Sharif University of Technology}, issn = {1026-3098}, eissn = {2345-3605}, doi = {10.24200/sci.2018.20797}, abstract = {Micro/Nano fluidic biochips are used to automate the clinical diagnosis, DNA sequencing, automated drug discovery and real time bio-molecular recognition. One of attractive usages of biochips is Lab-on-chip (LOC). Lab-on-Chip technology is a promising replacement for biomedical and chemical apparatus. Two main types of micro fluidic based biochips are used: continuous-flow based and digital micro fluidic biochips (DMFB). In DMFBs, liquids, in the form of droplets, are controlled independently and concurrently over a two dimensional array of cells (or electrodes).Digital micro fluidic biochips provide high ability to con gure and fault tolerance.In this paper, a new architecture for DMFB with purpose of balancing among the parameters of flexibility, efficiency, cost, and completion time of biological experiments, is presented. In the new architecture, a FPGA-based structure is used, which increase flexibility and paralellizing assay operations. Experiments showthat, the execution time of scheduling, routing, and simulation are improved in comparison with FPPC architecture about 2.54%, 18.76% and 12.52%, respectively in cost of 21% overhead in the number of controlling pins.}, keywords = {Micro fluidic Biochip,Physical Design,Architecture}, url = {https://scientiairanica.sharif.edu/article_20797.html}, eprint = {https://scientiairanica.sharif.edu/article_20797_f021dcd3ec742f9b3a41de1b03b7f153.pdf} }